4 doctors weighed in:
Is it safe to take benedryl and allegra (fexofenadine) in the same day?
4 doctors weighed in

Dr. Quan Nguyen
Internal Medicine - Allergy & Immunology
2 doctors agree
In brief: In general, yes,
Most common potential side effect would be sedation, however, Allegra is the least sedating antihistamine, so unless you are taking extra high dose of benadryl, (diphenhydramine) it would be quite safe.
Often in patients with difficult to control chronic hives, we have to use combination, sometime high dose, of antihistamines to treat the condition.

In brief: In general, yes,
Most common potential side effect would be sedation, however, Allegra is the least sedating antihistamine, so unless you are taking extra high dose of benadryl, (diphenhydramine) it would be quite safe.
Often in patients with difficult to control chronic hives, we have to use combination, sometime high dose, of antihistamines to treat the condition.
Dr. Quan Nguyen
Dr. Quan Nguyen
Thank
Dr. Steven Cohen
Internal Medicine - Allergy
In brief: Depends
Allegra 60 mg has about a 12 hour duration of action.
Benedryl at bedtime may provide relief of symptoms and help with sleep. I have used Allegra 180 mg at 8 am and zyrtec or Claritin (loratadine) at 8 pm in patients with difficult to control hives.

In brief: Depends
Allegra 60 mg has about a 12 hour duration of action.
Benedryl at bedtime may provide relief of symptoms and help with sleep. I have used Allegra 180 mg at 8 am and zyrtec or Claritin (loratadine) at 8 pm in patients with difficult to control hives.
Dr. Steven Cohen
Dr. Steven Cohen
Thank
Get help from a real doctor now
Dr. Peter Kurzweil
Board Certified,
46 years in practice
16M people helped
Continue
107,000 doctors available
Read more answers from doctors