No M-spike MM. Non-secretory multiple myeloma is myeloma that is diagnosed by the presence of plasma cells in the bone marrow and crab symptoms -- hypercalcemia, renal (kidney) problems, anemia, and bone problems (eg osteoporosis or lytic lesions) without an monoconal (m)-spike on serum protein electrophoresis (spep). A large study by kyle et al. At mayo suggested 7% of mm pts. Likely less now with flc testing.