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What is monoclonal gammopathy of undetermined significance (mgus)?

3 doctors weighed in
Dr. Stephen Noga
Internal Medicine - Oncology
1 doctor agrees

In brief: Blood & urine tests

Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte.
In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays.

In brief: Blood & urine tests

Mgus is the presence of an abnormal protrein in the blood made by a type of white blood cell called a plasmacyte.
In most cases, it is at a low level and is something that just has to be followed. However, it can be the precursor of the disease called multiple myeloma and as such a hematologist or medical oncologist will order tests to rule this out which may include blood, urine and simple x-rays.
Dr. Stephen Noga
Dr. Stephen Noga
Thank
Dr. Michael Thompson
Internal Medicine - Hematology & Oncology

In brief: Lab finding, pre-MM

Mgus is monoclonal gammopathy of undetermined significance.
It was called "benign monoclonal gammopathy" until ~1975 when robert kyle published an article in the nejm. Myeloma is thought to evolve from mgus at about 1% per year. Mgus risk factors can increase or decrease that risk.

In brief: Lab finding, pre-MM

Mgus is monoclonal gammopathy of undetermined significance.
It was called "benign monoclonal gammopathy" until ~1975 when robert kyle published an article in the nejm. Myeloma is thought to evolve from mgus at about 1% per year. Mgus risk factors can increase or decrease that risk.
Dr. Michael Thompson
Dr. Michael Thompson
Thank
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