30% dx; 50% life. Around 30% at diagnosis and about 50% throughout disease course. However, this may be less given newer anti-myeloma agents (?).
Renal and MM. Renal disease is a common problem in multiple myeloma. The serum creatinine is increased in almost 50% of patients at diagnosis. In approximately 20%, renal failure may be the presenting manifestation of mm.
Disease treatment. The only effective prevention for the renal disease associated with myeloma is the effective treatment of the underlying disease.
Avoid NSAIDs. In addition to treating the multiple myeloma it is important to avoid agents that can damage the kidneys specifically anti-inflammatory agents such as ibuprofen, etc.
Depends. This can best be answered by your treating physician. It often depends on age, other medical disorders, previous treatments, response to velcade (bortezomib). Most patients will have improvement in renal failure if this is the first treatment they receive, and the treatment usually includes velcade (bortezomib).