Injection site? Usually people asking about this are asking if Insulin can cause thickening of the skin at an injection site; the answer is yes. The solution is to stop using that site until the skin thins back down. After that, rotate your injection sites regularly, and never use one site more often than any of the others.
Why am I having a behive effect at the site of my insulin injection? Lots of burning and insulin doesn't absorb into skin
Lipodystrophy. This is a lump in the skin that forms when you keep on injecting in the same spot. One of the problem with this is the rejection of the injected medication. One thing you can do is rotate the injection sites around the belly button. Avoid injecting in the same area. Use different needle sizes...