What is chronic myelogenous leukemia (cml)?

White cell cancer. The bone marrow cells that produce granulocytes (needed to fight infections) grow out of control and are present in large numbers in the blood and other organs. The disease is quite treatable these days because of targeted therapy and long lasting remissions are possible in most people.
Chronic leukemia. CML is a type of chronic leukemia that is associated with a specific genetic change called the philadelphia chromosome. This genetic change in the cancer cells is targeted by a type of oral chemotherapy drug called a tyrosine kinase inhibitor. CML usually responds very well to these drugs although it is not cured with the pills. A stem cell transplant can be used in resistant cases.

Related Questions

What sort of disease is chronic myelogenous leukemia (c.M.L.)?

Bcr-abl. CML is a clonal disorder (cancer) of the white blood cells in the blood (= -emia part). Other leukemias include cll, aml, all, etc. CML is often diagnosed by testing on peripheral blood or bone marrow. The bcr-abl translocation (philadelphia chromosome) is found in cml. Treatment may be a variety of pills. The most common initial treatment has been gleevec (imatinib). Other drugs are available. Read more...

What's the type of inheritance of chronic myelogenous leukemia (cml)?

Not inherited. CML is associated with chromosome damage (the philadelphia chromosome). This is not inherited. The damage is to bone morrow stem cells and occurs long after birth. So the disease is not passed on to children. Read more...

What is chronic myelogenous leukemia?

A blood cancer. CML is a blood cancer that develops slowly (hence chronic). If untreated it will eventually be life threatening. It is associated a unique chromosomal injury, the philadelphia chromosome. New drugs (tkis) target this damage and reliably produce remissions in early stage patients that often are long lasting. Read more...
See below... Chronic myelogenous leukemia (CML) is a type of leukemia, which is a type of blood cancer. Like other chronic leukemias, CML is not particularly aggressive and can be successfully treated in most patients. Read more...

What kind of disorder is chronic myelogenous leukemia?

Myeloproliferative. It is in a group of disorders referred to as myeloproliferative neoplasms. There are essentially four: chronic myelogenous leukemia, essential thrombocytosis, polycythemia rubra vera and myelofibrosis. Hope this helps. Read more...

What complications arise when a person with chronic myelogenous leukemia (cml) becomes pregnant?

Difficult situation. This has happened to many women taking Imatinib (Gleevec) for CML. Most women have had a normal baby, others aborted the baby with help from a Gynecologist. I believe it is safe to carry the baby to term but there is some risk the drugs can harm the bay but it is not proven. So if you want to keep the baby then you should take this risk, but be closely monitored by a CML expert. First 3 months are. Read more...

Is chronic myelogenous leukemia classified as a genetic abnormality or a genetic disorder?

Yes. CML = genetic abnormality or a genetic disorder? I'm not sure what the difference is, but i'll try to extend what i think you are asking. CML is an acquired genetic abnormality. It is not (generally) an inheritied genetic trait/disorder. Read more...
Not sure... I'm not sure if there is a difference... CML is a type of leukemia caused by a genetic abnormalty, namely a translocation between chromosomes 9 and 22 resulting in the philadelphia chromosome. Read more...

Dangers of chronic myelogenous leukemia?

Can be fatal. This is a disease that was associated with a shortened life span. The discovery of a specific cancer cell mutation and medications that attack that mutation have dramatically affected the outcome. This is now a disease that people can live for many years and be functional and productive. Read more...

How should I treat chronic myelogenous leukemia?

CML. CML is associated with philadelphia chromosome that result in the abnormal bcr-abl fusion gene. This becomes the target of treatment in cml. Oral tyrosine kinase inhibitor (tki) is the treatment of cml. The 1st generation is gleevec. Other tki that is more specific to block the bcr/abl fusion gene also available- sprycel and tasigna (nilotinib). Bone marrow transplant is available only for specific case. Read more...
By oncologist. This is a somewhat indolent form of leukemia which responds to treatment and can be carried for many years without major illenss. You could only have known about this if you had a bone marrow and blood test from your oncologist whose recommendations i would continue to follow. Read more...
See below... First of all, the treatment for any type of leukemia should be coordinated by a hematologist/oncologist. To answer your question, chemotherapy is usually necessary like for any other type of leukemia; however, there is also a special drug that is central in the chronic treatment of cml, namely Gleevec (imatinib), with a specific benefit in this type of leukemia. Read more...