What changes in normal activities will be necessary after a blood and bone marrow transplant?

Depends. During the initial post transplant period immunity is severely compromised and people essentially are in isolation to avoid infection. Later on, if the transplant is successful and there are no serious complications quality of life can be significantly improved, even back to normal functioning with no limitation. Others have chronic complications that can interfere with normal activities.
See below. After being discharged from the hospital, a patient continues recovery at home (or at lodging near the transplant center if the patient is from out of town) for two to four months. Patients usually cannot return to full-time work for up to six months after the transplant. Other minor duty could done if the patient condition permit?