6 doctors weighed in:

How is adult cml treated?

6 doctors weighed in
Dr. Edward Gold
Internal Medicine
4 doctors agree

In brief: Targeted therapy

The current treatment uses drugs call kinase inhibitors that shuts off the oncogene that is believed to cause cml.
This oncogene, known as bcr/abl is caused by an exchange of genetic material at the chromosomal level.

In brief: Targeted therapy

The current treatment uses drugs call kinase inhibitors that shuts off the oncogene that is believed to cause cml.
This oncogene, known as bcr/abl is caused by an exchange of genetic material at the chromosomal level.
Dr. Edward Gold
Dr. Edward Gold
Thank
Dr. Stephen Noga
Internal Medicine - Oncology

In brief: Targeted therapy

The treatment of CML has changed dramatically in this decade.
Interferon and bone marrow transplant have almost entirely been replaced by drugs called tyrosine kinase inhibitors. Although we can not say that people are cured with these drugs, they remain in remission for many years with minimal side effects. CML is now truly a chronic disease very much like diabetes and rheumatoid arthritis.

In brief: Targeted therapy

The treatment of CML has changed dramatically in this decade.
Interferon and bone marrow transplant have almost entirely been replaced by drugs called tyrosine kinase inhibitors. Although we can not say that people are cured with these drugs, they remain in remission for many years with minimal side effects. CML is now truly a chronic disease very much like diabetes and rheumatoid arthritis.
Dr. Stephen Noga
Dr. Stephen Noga
Thank
Dr. Michael Thompson
Internal Medicine - Hematology & Oncology

In brief: Kinase inhibitor

Imatinib (gleevec, novartis) - http://www.
Ncbi.Nlm.Nih.Gov/pubmedhealth/pmh0000345/ although Dasatinib (sprycel, bms) is being considered (and is used) for front line treatment as well. Other tkis (tyrosine kinase inhibitors) are used for treatment. Clinical trials are ongoing. Bone marrow/stem cell transplant is still utilized for some patients.

In brief: Kinase inhibitor

Imatinib (gleevec, novartis) - http://www.
Ncbi.Nlm.Nih.Gov/pubmedhealth/pmh0000345/ although Dasatinib (sprycel, bms) is being considered (and is used) for front line treatment as well. Other tkis (tyrosine kinase inhibitors) are used for treatment. Clinical trials are ongoing. Bone marrow/stem cell transplant is still utilized for some patients.
Dr. Michael Thompson
Dr. Michael Thompson
Thank
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