Heterozygous for a1298c mutation on mthfr gene. Can you explain this to me?

Dubious lab test. There are several different alleles at the MTHFR locus and most (not all) of us in the pathology community are skeptical about the value of determining them, even in this era of defensive cover-your-butt medicine. The majority of people who are tested are told they have a "bad mutation" and one lab then offers dubious "nutritional supplements." Talk to a real geneticist.

Related Questions

Does heterozygous for MTHFR gene mutation affect pregnancy?, and what about taking synthetic folic acid supplement?

Controversial... Some studies have shown an association between the MTHFR gene mutation and recurrent miscarriages but this is controversial. Aside from this possibility, it doesn't cause problems with pregnancy. If you have this mutation, its a good idea to take folic acid, vitamin B-12 and Vitamen B-6. Aspirin is also sometimes recommended for women for who have had recurrent miscarriages. Best wishes! Read more...

Do all mthfr gene mutations benefit from folate over folic acid? Or certain stands? Is there different treatment for heterozygous v homozygous?

Need activated folat. You need to take methyl tetrahydrofolate (folic acid) to bypass your genetic abnormality or take massive doses of folate (folic acid)--such as 3 grams. You can determine what is adequate by measuring your homocysteine level. Folic acid and folate (folic acid) are the same thing. You may be thinking about folinic acid., . Read more...
What mutation? The pathology community is divided over mthfr testing. I'm undecided. A majority of people who take the test will be told they have an 'abnormal' result and are therefore in need of special supplements which they may then be offered by the folks who have done the test. Talk with your own physician and if necessary an authentic genetic counsellor. Read more...
Depends. Folic acid = synthetic. Methylfolate = natural. Folic acid also decreases folate receptors on cells and decreases folate binding proteins (this is bad). Avoid folic acid. Buy Solgar brand methylfolate 800 mcg or other brand. See how you feel in the am. If tired and foggy headed, take one methylfolate. More info: Http://drfairchild.blogspot.com/2013/10/mthfr.html . Read more...
MTHFR . MTHFR has several forms. And treatments can vary. Look here for additional information. http://mthfr.net/mthfr-c677t-mutation-basic-protocol/2012/02/24/ Read more...

Does having the mthfr gene mutation put me at risk for life threatning illness more than the average person? Is there anything I can do 2 help

Good question. This mutation affects an important biochemical function that will prevent the normal use of folic acid, a vitamin. Study of the chemistry is complex but ask your doctor for folinic acid since that becomes the missing factor. Read more...
Depends. Depends on which mutation you have, and if you have one or two mutations. Having two copies of the 677 mutation is a bigger deal than having one copy of the 1298. The 677 and 1298 mutations are each treated differently. But yes, there is help for them. Read more...
Answer's not in. This testing is promoted by a single lab and while there's some interesting data, you need to remember that a majority of people will get an "abnormal result". Rather than take the pricey vitamins that they'll try to sell you, I'd focus on staying fit and eating sensibly -- you lifestyle DOES make a huge difference as far as health goes. Best wishes. Read more...

My MTHFR gene mutation test says 'not detected' but the note below it says 'this assay detects the mutation C677T in MTHFR'. Does it mean I have it?

MTHFR mutations. MTHFR is the gene which produces methylenetetrahydrofolate reductase. Over 50 known mutations in this gene cause reduced function of the enzyme. The most common mutation causing homocystinuria is the C677T mutation, which among other problems increases the risk of stroke. I can't tell how many mutations your particular test could detect, but you do not have the C677T mutation. Read more...

Hi, I'm not really sure how this service works, but I'm going to send my question and see what happens. I have been having fertility treatment and was recently diagnosed with the homozygous C665T MTHFR gene mutation. There is a lot of conflicting inform

Sorry I. cannot offer more help than this: The "story" is still "OUT" and this gene abnormality has now been blamed for just about EVERYTHING from early heart disease to frequent miscarriages! I would be VERY CAUTIOUS about accepting ANY ADVICE particularly the INTERNET about this "condition" If this is a MAJOR issue consult with a Board Certified GENETICIST! My Opinion only...hope it helps..Good Luck Z. Read more...
Fasting homocysteine. This is a controversial an evolving issue. Most Obgyns would treat you with Heparin or Lovenox (enoxaparin) with a homozygous MTFHR mutation. The most up to date literature suggests testing a fasting homocysteine level and then only treating those who fail. Personally I base treatment of homozygous carriers on their past history of miscarriage or poor pregnancy outcome and infertility. Read more...
Habitual Miscarriage. There is much controversy surrounding this gene and the medical literature doesn't agree. However, personally, I have treated many women who repeatedly miscarry, and can't carry a baby to term, who responded (and carried to term) when treated. One treatment consists of taking daily an aspirin, Vitamin B-12, Vit B-6, and high-dose folic acid. Low-dose heparin is also sometimes used. Read more...

I am pregnant and have a mthfr gene mutation and I recently read that folic acid is not good for me or the baby and I should take folate instead?

Folic acid is folate (folic acid) Folic acid and folate are the same compound. Follow your gynecologists and hematologists recommendations. Folate is often prescribed during pregnancy in the field of psychiatry and neurology when patients are on anticonvulsants. I too have the same mutation that you have and i take folate every day. I have also been advised to take vitamin b6 and vitamin b 12 because of this. Your child should also be tested for this mutation and anyone else in your family.Best wishes. Read more...
MTHFR. If you've been tested for mthfr mutations and do have one, then your body may not do well with Folic Acid at all. You would benefit more from methylfolate since it bypasses the metabolic step that your system has trouble with. You need a functional medicine or integrative medicine doc who really knows mutations in this enzyme ; can advise you plus collaborate with your ob-gyn doc too. Read more...
Folic acid is bad. Folic acid is synthetic folate, and needs extra metabolic steps to turn it into a usable form. The body is very slow to convert it, and unmetabolized folic acid downregulates your folate receptors and folate binding proteins. This is a bad thing. Avoid folic acid, and take methylfolate instead. Read more...

I have a mutation of the mthfr gene and have had a thermal ablation. I have had 4 pregnancies and lost them. Uterine lining is 3.74 can I carry a baby?

Can't say. Can't say for sure, you'd need more specific testing of the uterine cavity, as well as more specifics on which mthfr mutation(s) you have. Even then, the answer woud be only an educated guess. With information you provide i'm most concerned about the impact of the ablation. Read more...
Low odds. The mthfr mutation is common and often not contributory to miscarriage. A thermal ablation of the uterine cavity, on the other hand, destroys much of the uterine lining where pregnancy needs to implant and can create a thin uterine lining. A thin lining may not be sufficient for pregnancy implantation and maintenance. Read more...
MTHFR Gene mutation. Here's some important information on the mthfr gene mutation... http://doccarnahan.blogspot.com/2013/10/whats-big-deal-about-methylation-update.html. Read more...

Positive for mthfr gene, ok so what do I do about that? Does it make me sick>?

Unclear. Are you a male or a female? Healthtap says you are male, but this is a lab result that typically is only checked in females. In past this was associated with possible increased risk for thrombosis (as it related to increased problems in pregnancy). Recently evidence for this being a problem has waned and many doctors are not longer screening or acting on a positive result. Read more...
MTHFR gene. There are several 'mutations' of this gene which affects the ability to convert the vitamin Folic Acid to active form. 2 copies of the bad gene can result in depression and cardiac and muscle problems. Treatment is with a supplement l-methyl folate (folic acid) or deplin. Read more...
MTHFR gene. Read more on methylation here http://doccarnahan.Blogspot.Com/2013/10/whats-big-deal-about-methylation-update.Html. Read more...
Controversial. The pathology community is divided over mthfr testing. I'm undecided. A majority of people who take the test will be told they have an 'abnormal' result and are therefore in need of special supplements which they may then be offered by the folks who have done the test. Talk with your own physician and if necessary an authentic genetic counsellor. Read more...
Depends. Those with MTHFR who eat lots of raw fruit and veges may not need methylfolate supplementation. Those who do not, may. Lifestyle and diet are big players in health and wellness. Optimizing both will help keep you healthy no matter what your genes are. Read more...