Can malabsorption from small bowel Crohn's decrease sensitivity of IBD blood panel? Wouldn't low serum globulin = fewer antibodies for test 2 detect?

>100,000 proteins. Globulin = total proteins less albumen, the most abundant protein. While globulins includes antibodies, it also includes many other proteins. Within the 5 antibody subclasses (IgM, IgG, IgA, IgE & IgD), with >100,000 specific binding activities for just IgG, the whole point is the ratio of relative targeting specifics, competing physiologic controls & responses. Globulin can be ? & targeting also ?