Can Zoloft (sertraline) and risperdal make u gain weight?

YES, esp. Zoloft (sertraline) Up to 25% of those on Zoloft (sertraline) & similar drugs gain 10 lbs or more. Resperidal also can case weight gain but in only about 5% of patients. Try exercising more. Don't stop Zoloft (sertraline) on your own but there are safe and effective natural alternatives; see & consider seeing a holistic MD to explore other options.