My friend has swelling her wrists, there like golfball size almost soft swelling, any ideas of what it could be? Any tests to rule out? Thank you.

Wrist swelling. It sounds like your friend has some type of inflammatory condition. Her primary doctor can order tests to determine what the cause may be (gout, rheumatoid, lupus, etc.).
A benign cyst. Most likely a cyst or ganglion, need observation, aspiration or excision.