Can toxic substances cause parkinson’s disease?

Parkinsonism. Yes. There is evidence that certain chemicals and pesticides can cause parkinsonism. We are now experiencing an epidemic of parkinsonism but it is not clear why this is happening.
Parkinsonia symptoms. Parkinson's disease is felt to be due to non-toxic brain degeneration but there have been parkinsonian symptoms reported with several toxins. The most commonly studied is mptp (an accidental product of mppp, an opioid, production). Mptp toxicity is rare. Please see md with details.

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