5 doctors weighed in:
Does anybody have a female child with fragile x syndrome?
5 doctors weighed in

Dr. James Ferguson
Pediatrics
3 doctors agree
In brief: Variable symptoms
The fragile x is usually passed through apparently asymptomatic carrier mothers who have a normally functioning x to cancel out the information of the altered x.
Detailed evaluation of some of these females has shown subtle deficiencies in some learning parameters, giving us an understanding that girls may show partial expression of the abnormality, but never to the degree of the male.

In brief: Variable symptoms
The fragile x is usually passed through apparently asymptomatic carrier mothers who have a normally functioning x to cancel out the information of the altered x.
Detailed evaluation of some of these females has shown subtle deficiencies in some learning parameters, giving us an understanding that girls may show partial expression of the abnormality, but never to the degree of the male.
Dr. James Ferguson
Dr. James Ferguson
Thank
1 comment
Dr. Glen Elliott
Like any X-linked disorder, girls have to be born with one affected X-Chromosome, or there would be no one to pass it along to the next generation. As noted, a single affected X-Chromosome usually produces, at most, subtle effects that are easily missed. Boys, who have only one X-Chromosome typically are much more affeced.
Dr. Cindy Juster
Pediatrics
In brief: Yes, it's possible.
Fragile x syndrome occurs in about 1 in 2500-4000 males and 1 in 7000-8000 females, and has been seen in all racial and ethnic groups.
As many as 1 in 130-250 women and 1 in 250-800 men are carriers, but only 1/3 of female carriers have decreased intelligence; females with fragile x syndrome are less likely than males to have impairment or physical abnormalities.

In brief: Yes, it's possible.
Fragile x syndrome occurs in about 1 in 2500-4000 males and 1 in 7000-8000 females, and has been seen in all racial and ethnic groups.
As many as 1 in 130-250 women and 1 in 250-800 men are carriers, but only 1/3 of female carriers have decreased intelligence; females with fragile x syndrome are less likely than males to have impairment or physical abnormalities.
Dr. Cindy Juster
Dr. Cindy Juster
Thank
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