10 doctors weighed in:
How does inheritance work in x-linked recessive diseases? 
10 doctors weighed in

Brian Fishman
Emergency Medicine
7 doctors agree
In brief: It's Complicated
In x-linked disorders, the allele for the trait is located on the x chromosome.
In recessive traits, both parents must pass on a copy of the recessive allele for the child to be affected. For a son (xy) to be affected, his mom must pass on the recessive allele (since the dad passes the y and is not a factor). For a daughter (xx), both parents must pass it.

In brief: It's Complicated
In x-linked disorders, the allele for the trait is located on the x chromosome.
In recessive traits, both parents must pass on a copy of the recessive allele for the child to be affected. For a son (xy) to be affected, his mom must pass on the recessive allele (since the dad passes the y and is not a factor). For a daughter (xx), both parents must pass it.
Brian Fishman
Brian Fishman
Answer assisted by Brian Fishman, Medical Student
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1 comment
Dr. Devon Webster
As a consequence, most X-linked syndromes show up in men (colorblindness, hemophilia)
Dr. James Ferguson
Pediatrics
2 doctors agree
In brief: Naked X expresssion
The carrier mother has 2 x chromosomes and the 2nd normal chromosome produces enough of the "normal" factors that mother is not symptomatic.
The male with only one x chromosome from the mother, has a y that cannot cover up the deficiency in mom's donated x, so the male is affected by whatever the condition is.

In brief: Naked X expresssion
The carrier mother has 2 x chromosomes and the 2nd normal chromosome produces enough of the "normal" factors that mother is not symptomatic.
The male with only one x chromosome from the mother, has a y that cannot cover up the deficiency in mom's donated x, so the male is affected by whatever the condition is.
Dr. James Ferguson
Dr. James Ferguson
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