A subtype of MS. This subtype represents about 10-15% of all ms, tends to occur at an older median adult age. It is characterized by progressive worsening neurological disability for at least 1 year, without relapses, and with MRI findings compatible with demyelinating disease of the central nervous system. Other medical and neurological conditions which may mimic this clinical course must be carefully excluded.
Less common form. About 9% of all ms cases are classified as ppms. These are more frequently males, and age of onset a bit later, mid 30's and beyond. These pts don't have relapses but just slow steady deterioration with progressive loss of neurological function. Tough to treat, as our standard meds do not seem effective. The drug Gilenya (fingolimod) may help but research not done.