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What s the difference between primary syphilis and neurosyphilis?

5 doctors weighed in
Dr. Martin Raff
Internal Medicine - Infectious Disease
4 doctors agree

In brief: Stage of disease

Primary syphilis is characterized by the chancre, a firm based ulcer which is not tender. Neurological involvement occurs after the spirochaete disseminates through the blood stream and can appear as meninigoencephalitis in secondary syphilis or in late stage syphilis it may manifest as permanent brain impairment with many symptoms and signs.

In brief: Stage of disease

Primary syphilis is characterized by the chancre, a firm based ulcer which is not tender. Neurological involvement occurs after the spirochaete disseminates through the blood stream and can appear as meninigoencephalitis in secondary syphilis or in late stage syphilis it may manifest as permanent brain impairment with many symptoms and signs.
Dr. Martin Raff
Dr. Martin Raff
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