13 doctors weighed in:
Donepezil effectiveness for vascular and Lewy body dementia?
13 doctors weighed in

6 doctors agree
In brief: Helpful in LBD
I routinely use donepezil effectively in my lewy body disease patients.
Although only 40-50% of them actually have cognitive improvements in the here & now, but we suspect it slows the progression of cognitive deterioration anecdotally. Can't comment on personal experience with vascular dementia.

In brief: Helpful in LBD
I routinely use donepezil effectively in my lewy body disease patients.
Although only 40-50% of them actually have cognitive improvements in the here & now, but we suspect it slows the progression of cognitive deterioration anecdotally. Can't comment on personal experience with vascular dementia.
Dr. Robert Hutchman
Dr. Robert Hutchman
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Dr. Alan Ali
Psychiatry
2 doctors agree
In brief: Donepezil
More effective in early dementias.

In brief: Donepezil
More effective in early dementias.
Dr. Alan Ali
Dr. Alan Ali
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Dr. Susan Uhrich
Psychiatry
2 doctors agree
In brief: There are some
Small studies which show that Aricept (donepezil) can increase functionality in vascular dementia and can help in lewy body dementia.

In brief: There are some
Small studies which show that Aricept (donepezil) can increase functionality in vascular dementia and can help in lewy body dementia.
Dr. Susan Uhrich
Dr. Susan Uhrich
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Dr. Theresa Redling
Internal Medicine - Geriatrics
In brief: Not FDA approved
Donepizil and other drugs in that class are not fda approved for other dementias(except ad).
The exception is Exelon (rivastigmine) approved for pd dementia. Howeverr, it is common to use these drugs for other dementias.

In brief: Not FDA approved
Donepizil and other drugs in that class are not fda approved for other dementias(except ad).
The exception is Exelon (rivastigmine) approved for pd dementia. Howeverr, it is common to use these drugs for other dementias.
Dr. Theresa Redling
Dr. Theresa Redling
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In brief: Memory drugs.
The only drug approved by the fda for parkinsons dementia is rivastigmine oral or patch.
Since lewy body dementia is similar, rivastigmine often is used there also. Both donepezil and galantamine (galantamine hydrobromide) have shown benefits in vascular dementia, and rivastigmine has not been studied. These latter 2 drugs are less likely to benefit lewy body patients.

In brief: Memory drugs.
The only drug approved by the fda for parkinsons dementia is rivastigmine oral or patch.
Since lewy body dementia is similar, rivastigmine often is used there also. Both donepezil and galantamine (galantamine hydrobromide) have shown benefits in vascular dementia, and rivastigmine has not been studied. These latter 2 drugs are less likely to benefit lewy body patients.
Dr. Bennett Machanic
Dr. Bennett Machanic
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