Can avapro (irbesartan) make you gain weight or make it difficult to lose weight?

Very unlikely. Usually you may see problems with weight with diabetic medications but not likely with meds for hypertension.
No. Most lokely you need to add a small dose of diuretics to the avapro avalide is a combination pill that will help.

Related Questions

Does atenolol or avapro (irbesartan) make it difficult to lose weight? How do you overcome this if diet and exercise are not working quickly?

Yes and no. B"sd avapro - basically a kind of weak diuretic atenolol is associated with weight gain, higher blood sugar and decreased blood flow to limbs. Substituition with a "balanced" beta blocker has been shown to give some mild weight loss, metabolic improvements and better blood flow to extremeties. Read more...