1 doctor weighed in:

Does the med, xyrem release histamine ? What do you suggest for mast cell disease ?

1 doctor weighed in
Dr. Hanul Bhandari
Internal Medicine - Sleep Medicine

In brief: See below

It is not known exactly how sodium oxybate (xyrem) works, but it is theorized that it works via agonizing the gaba receptor (promoting sedation among other effects).
It is not thought to work on histamine. It is recommended that you consult your pcp to evaluate for possible mast cell diseases, if it is concerning you based on symptoms. Hope that answers your question.

In brief: See below

It is not known exactly how sodium oxybate (xyrem) works, but it is theorized that it works via agonizing the gaba receptor (promoting sedation among other effects).
It is not thought to work on histamine. It is recommended that you consult your pcp to evaluate for possible mast cell diseases, if it is concerning you based on symptoms. Hope that answers your question.
Dr. Hanul Bhandari
Dr. Hanul Bhandari
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