I take cardizem cd 120mg and vytoryn 10/20 -it comes up as major interaction-should I notify my dr's about this. They are prescribed by 2 different drs?

Yes, notify. In general, any doctor prescribing for you needs to know all other medications that you are taking. Cardizem (diltiazem) can increase the level of Simvastatin in your blood (one of the components of vytorin). However, you are on a very small dose of the Simvastatin so the chance of a significant problem is extremely low. Blood tests of liver function would pick up a problem.