What can cause sudden elevation of liver levels in a patient with biliary cirrhosis on meds?

PBC Elevated LFT's. Primary biliary cirrhosis (pbc) itself is a terminal cirrhotic state of liver, requiring liver transplant. There is not much ast & alt enzymes left in liver to go up. Certain insults, can expedite liver damage, by elevated lft's: medicines metabolized by liver, alcohol, an obstruction in porta hepatis, ? Malignancy, need to be considered.

Related Questions

Please tell me what can cause sudden elevation of liver levels in a primary biliary cirrhosis pt on meds?

Repeat and see GI. Primary biliary cirrhosis is an autoimmune disease of the liver that affect women more than men. Medications for treatment include ursodeoxycholic acid and steroids for acute flairs. Transient elevations may occur for a variety of reasons: 1) exacerbation of pbc; 2) injury to liver from another cause, e.g. Alcohol, tylenol; 3) viral infection, hepatitis or other virus. Repeat labs and see md. Read more...

What is primary biliary cirrhosis (liver) like?

It's variable. Depends on how long you have had it. Usually without symptoms early in the disesae. May be associated with itching, hypythyroidism, fatigue, osteoporosis and dry eyes. Can progress to cirrhosis over time. If you have pbc, you should talk with your doctor about what stage your disease is. Read more...

Liver diagnosis 60 f -ast302/alt438 ANA pos. Us neg liver biopsy 1st dr diagnosis pri biliary cirrhosis. 2nd dr autoimmune hep. Diangosis ursodiol 5wk retest. Do you agree?

Yes, need follow up. You have a combination of primary biliary cirrhosis (pbc) and autoimmune hepatitis (aih). The treatments are different, ursodeoxycholic acid is used to treat pbc, but may not bring down the ast/alt elevation associated with aih. If the urso does not bring down the ast/alt, you may need additional medications, such as steroids or azathioprine, to control the aih. Read more...
Show it around. Get several pathologists' opinions. What was the anti-smooth-muscle / f-actin titer and what was the anti-mitochondrial / pyruvate dehydrogenase antibody titer, and were lkm or other other labs run? We pathologists actually have systems for scoring liver biopsies to distinguish the two, important for determining treatment. Wishing you luck. Read more...
This requires . careful analysis of laboratory data and review of pathology. Patients can be diagnosed with what is called autoimmune hepatitis -psc overlap. Meaning both diseases can be seen. Diagnosis of psc requires characteristic findings on an mrcp(Mri of liver and bile ducts). psc is sometimes suspected on a biopsy but sometimes not obvious however an mrcp is helpful. Please consult me if interested . Read more...