9 doctors weighed in:

How do you treat patients who have both myelodysplasia and hemochromatosis?

9 doctors weighed in
Dr. Ester Kwok
Internal Medicine
4 doctors agree

In brief: See one's hematologi

Treatment of myelodysplasia and hemochromatosis depends on the severity of the individual diseases and which one is causing the biggest problem. A hematologist/oncologist can sort this out.

In brief: See one's hematologi

Treatment of myelodysplasia and hemochromatosis depends on the severity of the individual diseases and which one is causing the biggest problem. A hematologist/oncologist can sort this out.
Dr. Ester Kwok
Dr. Ester Kwok
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Dr. Matthew Fero
Internal Medicine - Oncology
2 doctors agree

In brief: Chelation Therapy

Myelodysplasia causes lack of normal blood cell production, and many patients need RBC transfusions.
This can result in iron overload, since humans lack a way to excrete iron. Hemochromatosis is a genetic condition that alters iron metabolism and makes patients more susceptible to organ injury from iron overload. Desferoxamine is an agent that chelates iron and can be used to reduce its levels.

In brief: Chelation Therapy

Myelodysplasia causes lack of normal blood cell production, and many patients need RBC transfusions.
This can result in iron overload, since humans lack a way to excrete iron. Hemochromatosis is a genetic condition that alters iron metabolism and makes patients more susceptible to organ injury from iron overload. Desferoxamine is an agent that chelates iron and can be used to reduce its levels.
Dr. Matthew Fero
Dr. Matthew Fero
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Dr. Liawaty Ho
Internal Medicine - Hematology & Oncology

In brief: Very complicated

Depend on severity of the disease.
Many times mds can be maintained with growth factor to keep hemoglobin and WBC at certain level, if one also has hemohromatosis-is it homozygous or heterozygous/carrier? Phlebotomy prob not needed for a carrier.Watchout iron intake, iron chelator if can't do phlebotomy. Hypomethylating agent if needed. Treatment is complicated and individualized if you have both.

In brief: Very complicated

Depend on severity of the disease.
Many times mds can be maintained with growth factor to keep hemoglobin and WBC at certain level, if one also has hemohromatosis-is it homozygous or heterozygous/carrier? Phlebotomy prob not needed for a carrier.Watchout iron intake, iron chelator if can't do phlebotomy. Hypomethylating agent if needed. Treatment is complicated and individualized if you have both.
Dr. Liawaty Ho
Dr. Liawaty Ho
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1 comment
Dr. Liawaty Ho
there are so many factors have to calculate in. further discussion with your hematologist/oncologist needed. It is not enough to explain everyhting in 400 words.
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