5 doctors weighed in:
If both parents must have a mutation in their CF genes in order to create a child with cf, how common are carriers?
5 doctors weighed in

Dr. Derrick Lonsdale
Preventive Medicine
3 doctors agree
In brief: See below
Each time carrier parents have a child they have one chance in 4 of each passing the mutated gene and having a child with cf, two chances in 4 of each passing it from one parent (carriers) and one chance in 4 of a two normal gene healthy non carrier.This is classical mendelian inheritance but there may be more information now.
Remember that it is a 4-sided "penny" that you toss each time!

In brief: See below
Each time carrier parents have a child they have one chance in 4 of each passing the mutated gene and having a child with cf, two chances in 4 of each passing it from one parent (carriers) and one chance in 4 of a two normal gene healthy non carrier.This is classical mendelian inheritance but there may be more information now.
Remember that it is a 4-sided "penny" that you toss each time!
Dr. Derrick Lonsdale
Dr. Derrick Lonsdale
Thank
Dr. James Ferguson
Pediatrics
In brief: Difficult question
A pair of the most common defect in the CF gene is responsible for about 80% of cases, but there are dozens of other mutations that can be involved is individual cases.
The carrier state in populations varies by ethnic groups. Numbers from 1/27 to 1/50 or so are often sited.Carrier detection is possible through gene testing.

In brief: Difficult question
A pair of the most common defect in the CF gene is responsible for about 80% of cases, but there are dozens of other mutations that can be involved is individual cases.
The carrier state in populations varies by ethnic groups. Numbers from 1/27 to 1/50 or so are often sited.Carrier detection is possible through gene testing.
Dr. James Ferguson
Dr. James Ferguson
Thank
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