Could I take tylenol (acetaminophen) 3 with pain pills pm that has diphenhydramine?

Med interaction. Tylenol (acetaminophen) 3 has a morphine class of medicine, which can make some people sleepy or depress the body's functions: decreased breathing, slow down the gut and decrease the heart rate. This is especially true in large amounts. If you add diphenhydramine, another sedating medication, could be detrimental if the dose is too high for you. .