6 doctors weighed in:

What are the signs and symptoms of thalassemia?

6 doctors weighed in
Dr. Robert Kwok
Pediatrics
4 doctors agree

In brief: None to severe/fatal

Alpha thal: silent carriers have no signs/symptoms; Alpha trait has mild anemia; HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's (severe) is usually fatal before birth.
Beta thal: beta trait has mild anemia; beta intermedia may have weakness, pallor, less growth, and need some transfusions; beta major (cooley's, severe) needs lifelong transfusions.

In brief: None to severe/fatal

Alpha thal: silent carriers have no signs/symptoms; Alpha trait has mild anemia; HGB h (moderate) may have weakness, pallor, less growth, and need some transfusions; bart's (severe) is usually fatal before birth.
Beta thal: beta trait has mild anemia; beta intermedia may have weakness, pallor, less growth, and need some transfusions; beta major (cooley's, severe) needs lifelong transfusions.
Dr. Robert Kwok
Dr. Robert Kwok
Thank
Dr. Michael Engel
Pediatrics - Hematology & Oncology

In brief: Thalassemia

Thalassemia is a deficiency in the production of one of the globin chains (alpha or beta) that make up hemoglobin.
Normally synthesis of these is balanced. When imbalanced, one globin accumulates relative to the ither forming inclusions that are damaging to the red cells that contain them. There are many thal variants that manifest a wide severity of symptoms from none to transfusion dependence.

In brief: Thalassemia

Thalassemia is a deficiency in the production of one of the globin chains (alpha or beta) that make up hemoglobin.
Normally synthesis of these is balanced. When imbalanced, one globin accumulates relative to the ither forming inclusions that are damaging to the red cells that contain them. There are many thal variants that manifest a wide severity of symptoms from none to transfusion dependence.
Dr. Michael Engel
Dr. Michael Engel
Thank
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