4 doctors weighed in:

How is thalassemia inherited?

4 doctors weighed in
Dr. Robert Kwok
Pediatrics
2 doctors agree

In brief: From Mom and/or Dad

Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells.
Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad.

In brief: From Mom and/or Dad

Alpha thalassemia is caused by a mutation in one or more of the 4 genes that code for (holds the dna for) Alpha globulin, which is needed to make hemoglobin for new red blood cells.
Beta thalassemia is caused by a mutation in one or both of the 2 beta globulin genes. Mom and/or dad can carry the mutations. A child can inherit a mutation from mom, from dad, or from both mom and dad.
Dr. Robert Kwok
Dr. Robert Kwok
Thank
Dr. Richard Pollard
Anesthesiology

In brief: Genetically

The full expression of thalassemia requires the genetic mixing of both defective genes from the male and female.

In brief: Genetically

The full expression of thalassemia requires the genetic mixing of both defective genes from the male and female.
Dr. Richard Pollard
Dr. Richard Pollard
Thank
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