Unusual. Except for high dosages of phenothiazine derivatives.
Hyperthermia. Hyperthermia, not malignant hyperthermia, is the primary risk with use of ecstasy. Malignant hyperthermia is an inherited disease usually triggered by general anesthesia.
Several. Mh usually occurs in response to anesthetics used in or or dental offices. There are some stimulant drugs (ecstasy) that may be associated. Symptoms include high body temperature (muscle break down), profuse sweating, muscle rigidity (esp in jaw), rapid & irregular heart beat, rapid breathing, confusion, flushing, coca cola colored urine, low blood pressure & shock. Life threatening disorder.
My first cousin once removed has malignant hyperthermia. What are my chances of having it, what to do?
Get tested. Malignant hyperthermia can run in families. Although your cousin is not in your immediately family you may still be affected. To be tested a muscle biopsy will need to be taken and sent to. A specialty lab for testing. To be safe avoid certain anesthetics so let your anesthesiologist know if you ever need surgery. They can avoid triggering agents.
What drugs are used in oral contious sedation for dental work? With family history of malignant hyperthermia is there a risk?
Yes, but managable. Typically, valium and versed is used in IV conscious sedation for dental treatment, though sometimes just oral meds may be used. Your family history of mh should be investigated and can be managed. I would recommend that you see an oral and maxillofacial surgeon instead of a general dentist.
Little to no risk. Most oral conscious sedation (key word here is "conscious") are in the benzodiazepene class of drugs such as xanax, (alprazolam) valium, and ativan. One in particular called Halcion is used often in oral conscious sedation for dental work because it has quite an amnesic effect. Basically you will be awake still and be able to maintain your own airway but you will remember little to none of the procedure.
Little to no risk. Because most dental sedation is done using the class of drugs known as benzodiazapines, you can rest easy about mh occurring with dental sedation techniques. Mh occurs more often using general anesthetic agents.
Oral sedation. With benzodiazepines or narcotics should be fine. Make sure your dentist is aware you have a family history of mh.
Many....but.... I personally consult with a board certified anesthesiologist before sedating any patients with a family history of malignant hyperthermia. Many drugs can be used but this has to be dealt with on a case by case basis. If there is a any probability of malignant hyperthermia occurring I will do the case with the medical anesthesiologist present.
Fairly low risk. The drugs typically used in dental sedation are not triggers for mh. With your history though, would suggest having a board certified anesthesiologist care for you to make sure you receive no triggering drugs. Another option is to be tested for mh to determine if you are susceptible. This would be useful information if you ever require general anesthesia in the future.
MH- temp, HR, etc. Mh is an inherited disease that is typically uncovered after the affected person gets anesthesia for surgery. Symptoms include muscle rigidity, fast, irregular heart rate, rapid rise in body temperature to 104f or higher. Mh can lead to muscle breakdown, kidney failure and death. There may be a family history of mh or unexplained death during anesthesia. Mh differs from hyperthermia (heat stroke).
Anesthetic reaction. Malignant hyperthermia is a serious, possibly life threatening reaction to certain anesthetic agents including succinylcholine and inhaled anesthetic gases. This condition is often inherited, and involves a mutation of a gene in muscles involved in calcium release. When exposed to triggering agents, the muscles undergo excessive metabolism, leading to muscle breakdown and heat, which cause death.