8 doctors weighed in:

Can anyone tell me what causes celiac disease to begin in the first place?

8 doctors weighed in
Dr. Jill Carnahan
Family Medicine
7 doctors agree

In brief: Genetics

If you are born with genetic mutations, hla types dq2 or dq8, this predisposes you to develop celiac disease.
Then it is usually an environmental trigger, like abnormal gut microbes or infection that triggers it from being a genetic predisposition into an active condition. The condition starts with damage the the microvilli that line the gut and eventually ends with total villous atrophy.

In brief: Genetics

If you are born with genetic mutations, hla types dq2 or dq8, this predisposes you to develop celiac disease.
Then it is usually an environmental trigger, like abnormal gut microbes or infection that triggers it from being a genetic predisposition into an active condition. The condition starts with damage the the microvilli that line the gut and eventually ends with total villous atrophy.
Dr. Jill Carnahan
Dr. Jill Carnahan
Thank
1 comment
Dr. Bennett Machanic
Excellent summary
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