5 doctors weighed in:

How do caffeine and modafinil interact?

5 doctors weighed in
Dr. J. Kirk Clopton
Psychiatry
3 doctors agree

In brief: Synergestically

Caffeine and Modafinil can increase energy and cognition by working on separate systems.
The effect of Modafinil tends to be sustained over time, whereas, the body developed tolerance to the effects of caffeine leading to the need to constantly increase the amount of caffeine to get the same effect.

In brief: Synergestically

Caffeine and Modafinil can increase energy and cognition by working on separate systems.
The effect of Modafinil tends to be sustained over time, whereas, the body developed tolerance to the effects of caffeine leading to the need to constantly increase the amount of caffeine to get the same effect.
Dr. J. Kirk Clopton
Dr. J. Kirk Clopton
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Dr. Thomas Namey
Internal Medicine - Rheumatology

In brief: Can be additive.

Athough both are stimulatory and erase fatugue, their neural mechisms of action are very different.
Ingestion of large amounts of caffeine can cause tremor and excess anxiety, or poor sleep. Read my article and decide. Small (2 or 3 cups) amounts of coffee drunk sequentially after Modafinil or Armodafinil (is not a good idea. The article:( acr.Confex.Com/acr/2007/webprogram/paper7848.Html).

In brief: Can be additive.

Athough both are stimulatory and erase fatugue, their neural mechisms of action are very different.
Ingestion of large amounts of caffeine can cause tremor and excess anxiety, or poor sleep. Read my article and decide. Small (2 or 3 cups) amounts of coffee drunk sequentially after Modafinil or Armodafinil (is not a good idea. The article:( acr.Confex.Com/acr/2007/webprogram/paper7848.Html).
Dr. Thomas Namey
Dr. Thomas Namey
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