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What will be the chances of birthdefects in my children if i marry a maternal cousin whose parents are first cousins? No cousin marriages in my family

2 doctors weighed in
Dr Johanna Fricke
Pediatrics - Developmental & Behavioral

In brief: Pre-marital genetic

Counseling will help define your risk of autosomal recessive genetic disorders, in which each parent carries the harmful gene mutation.
In pakistan, first-cousin marriage has a 7.9% risk of infant mortality ; a 5-6% risk for birth defects, but having multiple generations of first-cousin marriages increases chances of having a child with a recessive disorder 13 times that of the general population.

In brief: Pre-marital genetic

Counseling will help define your risk of autosomal recessive genetic disorders, in which each parent carries the harmful gene mutation.
In pakistan, first-cousin marriage has a 7.9% risk of infant mortality ; a 5-6% risk for birth defects, but having multiple generations of first-cousin marriages increases chances of having a child with a recessive disorder 13 times that of the general population.
Dr Johanna Fricke
Dr Johanna Fricke
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1 comment
Dr Johanna Fricke
In researching this, I learned that 50% of current marriages in Pakistan & 55% of current marriages in Paki-Britons are first-cousin marriages. The problem is that having more than one generation of first-cousin marriage in a specific population means the couple may be more genetically linked than their relationship shows.
Dr James Ferguson
Pediatrics

In brief: Risks in mariage

Geneticists estimate that we all carry at least 4 gene defects that when paired with another carrier could produce chronic disease (like cystic fibrosis) or death( metabolic disorder).
Any marriage between close relatives increases this statistical risk. Marrying outside the family decreases risk substantially for rare afflictions. Your risk could be as high as 25% for kids with some disorders.

In brief: Risks in mariage

Geneticists estimate that we all carry at least 4 gene defects that when paired with another carrier could produce chronic disease (like cystic fibrosis) or death( metabolic disorder).
Any marriage between close relatives increases this statistical risk. Marrying outside the family decreases risk substantially for rare afflictions. Your risk could be as high as 25% for kids with some disorders.
Dr James Ferguson
Dr James Ferguson
Thank
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