12 doctors weighed in:

Does a rising psa after a radical prostatectomy mean cancer?

12 doctors weighed in
4 doctors agree

In brief: Yes

This is called psa recurrence.
Depending on pathological factors you can predict the chances. Radiation and or hormone ablation are often next treatment steps if surgery was first treatment.

In brief: Yes

This is called psa recurrence.
Depending on pathological factors you can predict the chances. Radiation and or hormone ablation are often next treatment steps if surgery was first treatment.
Dr. Richard Sarle
Dr. Richard Sarle
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1 comment
Dr. Andrew Turrisi
depending on the time after surgery, and the pace of and height of the PSA, one might check a bone scan and/or CT-pelvis/abd to check for nodes.
Dr. Naveen Kella
Urology - Oncology
3 doctors agree

In brief: Yes

There should be no psa rise after surgery.
However, acting on a rise depends on your life expectancy and how quickly the psa is rising.

In brief: Yes

There should be no psa rise after surgery.
However, acting on a rise depends on your life expectancy and how quickly the psa is rising.
Dr. Naveen Kella
Dr. Naveen Kella
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Dr. Andrew Turrisi
Radiation Oncology
2 doctors agree

In brief: If the prostatectomy

Removed all the prostate, post op psa should be 0 in 30 - 60 days, if it isn't either prostate tissue, or prostate cancer remains, either in the prostate bed for the former, or elsewhere for the latter. The pathology report usually details margins of resection, and capsule penetration.
This can occur with any method of prostatectomy.

In brief: If the prostatectomy

Removed all the prostate, post op psa should be 0 in 30 - 60 days, if it isn't either prostate tissue, or prostate cancer remains, either in the prostate bed for the former, or elsewhere for the latter. The pathology report usually details margins of resection, and capsule penetration.
This can occur with any method of prostatectomy.
Dr. Andrew Turrisi
Dr. Andrew Turrisi
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Dr. Gurmukh Singh
Pathology
2 doctors agree

In brief: Likely

A rising level of psa or any other tumor marker indicates increasing tumor mass.
Therefore a rising psa would suggest recurrence of the tumor.

In brief: Likely

A rising level of psa or any other tumor marker indicates increasing tumor mass.
Therefore a rising psa would suggest recurrence of the tumor.
Dr. Gurmukh Singh
Dr. Gurmukh Singh
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Dr. Devon Webster
Internal Medicine - Oncology
1 doctor agrees

In brief: Yes

Psa comes from prostate cells.
So if you've had your prostate completely removed, you should not have an elevated psa. If you do, it means there are prostate cells somewhere in your body. This usually means a recurrence of prostate cancer. Sorry, i'm sure that's not what you wanted to hear. Talk to your urologist or oncologist for more info, and best wishes.

In brief: Yes

Psa comes from prostate cells.
So if you've had your prostate completely removed, you should not have an elevated psa. If you do, it means there are prostate cells somewhere in your body. This usually means a recurrence of prostate cancer. Sorry, i'm sure that's not what you wanted to hear. Talk to your urologist or oncologist for more info, and best wishes.
Dr. Devon Webster
Dr. Devon Webster
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