Help! Need to know if there's any OTC medicine that is similar or works like fluconazole?

Yeast Infections. There is not an over the counter pill for treatment of yeast (like the fluconazole), but there are over the counter topical treatments for yeast. These are creams or vaginal suppositories. Sometimes they work. Sometimes they don't. They would not cause any harm, though, unless you have an unexpected reaction.