Vaginal supos. Progesterone od? 2000 mg per day for 2 days, before only 1100 mg over the 7 weeks of pregnancy, is new bump in vagina, edema? Serious?

Doubt it. If there is a new bump/mass you should have your doctor examine it, but highly unlikely a discrete mass is caused by Progesterone suppositories. Edema is diffuse and would not mostly be felt as a mass. In 20 years i've not seen this from Progesterone suppositories, but alternatives include intravaginal Crinone (progesterone gel) gel and intramuscular shots of Progesterone in oil.
Not sure. Please have your OB md check out the bump and possibly biopsy it for confirmation of what it is.