4 doctors weighed in:

Can an oopherectomy reduce breast cancer recurrence in premenopausal women?

4 doctors weighed in
Dr. Ed Kaplan
Internal Medicine - Hematology & Oncology

In brief: YES for ER positive

Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women.
Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies.

In brief: YES for ER positive

Oopherectomy has been proven to reduce recurrence in estrogen-receptor positive pre-menopausal women.
Prior to tamoxifen, it was a commonly used treatment for metastatic disease and is now known to reduce recurrence in high-risk premenopausal hormone-receptor positive breast cancer, even without the use of other endocrine therapies.
Dr. Ed Kaplan
Dr. Ed Kaplan
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Dr. Andrew Turrisi
Radiation Oncology

In brief: Controversial

...But maybe yes, in er + cases.

In brief: Controversial

...But maybe yes, in er + cases.
Dr. Andrew Turrisi
Dr. Andrew Turrisi
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2 comments
Dr. Ed Kaplan
Not controversial at all. But only effective in the right setting (ER positive and post-menopausal).
Dr. Ed Kaplan
mistake- PRE-menopausal

In brief: Yes

But that's a pretty extreme step.
Basically, any reduction in estrogen can reduce risk. Pregnancy suppresses estrogen production, which is why nulliparity (not having babies) raises the risk. Nuns have higher brca risk! so while oophorectomy will reduce risk, it is also possible to reduce risk with medications. Raloxifene is drug which works very well with few side effects. See your doctor!

In brief: Yes

But that's a pretty extreme step.
Basically, any reduction in estrogen can reduce risk. Pregnancy suppresses estrogen production, which is why nulliparity (not having babies) raises the risk. Nuns have higher brca risk! so while oophorectomy will reduce risk, it is also possible to reduce risk with medications. Raloxifene is drug which works very well with few side effects. See your doctor!
Dr. Scott Welker
Dr. Scott Welker
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1 comment
Dr. Scott Welker
You're most welcome :-)
Dr. C Jeffrey Holmes
Family Medicine

In brief: Quite possibly

Removing the ovaries dramatically decreases your estrogen production.
Any estrogen responsive or estrogen receptor positive cancers will lose that stimulation, and decrease the chance of developing that type of cancer. Recurrence risk of estrogen receptor positive cancers will decline.

In brief: Quite possibly

Removing the ovaries dramatically decreases your estrogen production.
Any estrogen responsive or estrogen receptor positive cancers will lose that stimulation, and decrease the chance of developing that type of cancer. Recurrence risk of estrogen receptor positive cancers will decline.
Dr. C Jeffrey Holmes
Dr. C Jeffrey Holmes
Thank
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