What mutations cause fetal alcohol syndrome facial features in a baby or child, whose mother was a non-drinker?
First of all... ...Alcoholics frequently deny that they drink; so if there are features suggesting fas, you have to be sure the mother really is a non-drinker. That said, cornelia de lange syndrome, velocardiofacial syndrome (vcfs), & dubowitz syndrome - & probably others - share features with fas, though they are rarer. A precise diagnosis requires a thorough exam and lab testing by an expert in this field.
Fetal alcohol. The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade ofn-methyl-d-aspartate (nmda) glutamate receptors and excessive activation of gabaa receptors], triggers widespread apoptotic neurodegeneration in the developing rat forebrain. Vulnerability coincides with the period synaptogenesis.