Can hydroxyzine help with the head pressure symptom of a panic attack? I'm also taking Zoloft (sertraline) 50mg. Is this a good combination?

It can! Hydroxyzine has a sedative effect, generally a very strong one depending on the dose. That is, the more Hydroxyzine the greater the sedation. Combining medications is always a process that deserves attention because you want to avoid interactions. In this case there is no concern with zoloft (sertraline) and hydroxyzine. However, you want to be careful with metoprolol and zoloft (sertraline).