Are there any medications that can treat smallpox symptoms?

See below. No cure for smallpox exists. Treatment would focus on relieving symptoms and keeping the person from becoming dehydrated. Antibiotics may be prescribed if the person also develops a bacterial infection in the lungs or on the skin.
Treatment supportive. When it was prevalent, smallpox was treated with supportive measures like fluids, rest, attention to complications etc. Since the last cases in the US were in 1949 & worldwide in 1977 there are no active cases to study the newer medications.
Smallpox. The WHO announced World-wide eradication of Smallpox on May 8 1980. A Smallpox patient should be isolated in a negative-pressure room until all scabs have fallen off. Provide intravenous or oral hydration wi electrolyte/ fluid monitoring. The person should be vaccinated as soon as possible after exposure. Wound care is important. Use ventilatory support if required. Although there is no specific.