See below. Als (lou gehrigs disease) is a degenerative condition in which the motor nerves in the spinal cord and the brain stem (called Alpha motor neurons) degenerate. This caused the muscles to fail because they are not getting adequate electrical signals from the nerves. It usually start with weakness in the hands and feet and then unfortunately progresses. It also involves muscles of speech, swallowing.
See. Lougehrig. Com.
Destruction. ALS or Lou Gehrig's disease causes death of motor nerve cells in brain and spinal cord, and unfortunately, damage is progressive, irreversible, and without cure. Although muscle weakness and atrophy in limbs can be seen, involvement of tongue, swallowing, and breathing can be seen terminally.