How important is the hypothalamus gland in regulating weight?

Central. Hypothalamic disease affects the pituitary and the target organs controlled by the pituitary: adrenals, ovaries, testes, and thyroid. Hypothalamic damage can result from malnutrition, anorexia and bulimia, surgery, or head trauma causing disruptions in body temperature regulation, growth, weight, sodium and water balance, milk production, emotions, and sleep cycles control center for endocrine.