6 doctors weighed in:
How do you explain the experience of euphoria from first dose of zoloft (sertraline)?
6 doctors weighed in

3 doctors agree
In brief: Multiple answers
Euphoria from zoloft (sertraline) is rare but possible.
Serotonin stimulation can have a mini l.S.D. Effect&can cause excitation. Any antidepressant can induce mania. Dream enhancement from an ssri can seem euphoric. Early relief of depression can be interpreted as a good feeling. Interactions between zoloft (sertraline)&other prescription medications, herbal and nutritional agents &/or recreational drugs can fuel a high.

In brief: Multiple answers
Euphoria from zoloft (sertraline) is rare but possible.
Serotonin stimulation can have a mini l.S.D. Effect&can cause excitation. Any antidepressant can induce mania. Dream enhancement from an ssri can seem euphoric. Early relief of depression can be interpreted as a good feeling. Interactions between zoloft (sertraline)&other prescription medications, herbal and nutritional agents &/or recreational drugs can fuel a high.
Dr. Stephan Quenztel
Dr. Stephan Quenztel
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Dr. Steven Reidbord
Psychiatry
2 doctors agree
In brief: A few possibilities
1. Zoloft (sertraline) is mildly stimulating (like caffeine) for many people.
This side-effect may be interpreted as euphoria. 2. Manic reactions are possible from antidepressants. This may feel euphoric, but usually has an irritable or edgy component, and would continue & worsen with further doses. 3. It may be a psychological reaction to getting help, feeling optimistic after long discouragement, etc.

In brief: A few possibilities
1. Zoloft (sertraline) is mildly stimulating (like caffeine) for many people.
This side-effect may be interpreted as euphoria. 2. Manic reactions are possible from antidepressants. This may feel euphoric, but usually has an irritable or edgy component, and would continue & worsen with further doses. 3. It may be a psychological reaction to getting help, feeling optimistic after long discouragement, etc.
Dr. Steven Reidbord
Dr. Steven Reidbord
Thank
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