Can I be re-infected with mono?

Mononucleosis. Usaly you get a relapse of symptoms with or without complications.
Not from EBV virus. Mono is caused by the ebv virus. Once a person catches ebv, it seems to stay in one's body, and can re-activate to cause mono-like symptoms more than once. Re-activation is sort of like being re-infected by one's own virus, but it is not a true re-infection by an outside virus. Occasionally, other germs can cause a "mono-like" illness.