What are factors contributing to cancer cachexia?

Cancer and treatment. The greek words kakos="bad things", & hexus="state of being. Cancer cachexia is characterized by diminished nutrient intake and progressive tissue depletion, both of which lead to weight loss. Cytokine activation and tumor-derived cachexia-inducing substances are thought to be the causes. In some cases, cancer treatment may also contribute to loss of lean body mass in patients with advanced cancer.
Multiple. Increased use of energy by tumor, release of cytokinces from tumor, loss of appetite, increased metabolic rate contribute to cachexia in tumors.

Related Questions

How can you tell if you have significant loss of skeletal muscle from cancer cachexia?

Cachexia. Simple inspection of limbs can reveal significant loss of muscle bulk in any illness. This would also be accompanied by a gaunt and sunken facial appearance. In other words, cachexia is quite obvious and not a subtle state of health.

Is only decrease in food intake responsible for the weight loss assicated with cancer cachexia?

No. The mechanism is poorly understood, but even nutrition cannot reverse this condition. In cancer patients, it is thought to involve inflammatory cytokines like tumor necrosis factor-alpha (tnf-α), also called cachexin for this reason. Interferon gamma (ifnγ), and interleukin 6 (il-6), as well as the tumor-secreted proteolysis inducing factor (pif) are other cytokines involved.
No. There is also an increase in calorie expenditure.

Would I know if I had cancer cachexia? I've lost a couple of pounds and feel like I have no muscles, especially in my upper arms. I'm thin.

Even when you are. Thin, losing a couple of pounds should not be of large concern. Also, we would need to determine if you truly are weak (your muscles are losing power) or if they just seem smaller/thinner. Finally, I don't believe the term cancer cachexia is applied to anyone unless they actually have been diagnosed with cancer. I am concerned about your nutrition and body weight; seek medical/nutritional consult.

Mom has advanced ovarian cancer diagnosed in 2006. What is the best solution for cancer cachexia? Megestrol acetate is not helping, nor protein food

Cannabis. Cannabis is a natural appetite stimulant. It works and because of my hospice work, is why I worked so hard to legalize it here in the U.S.
Cancer cachexia solu. Unfortunately once cancer cachexia sets in, the tumor is usually very far advanced and medications usually do not help much.
Cancer cachexia. This is a challenge. Options include liquid food supplements, such as protein shakes or Ensure, egg whites, Quinoa, Yogurt, puddings. Appetite stimulants like megestrol are effective. Dose matters - raising the dose might help. Cannabis can help. Feeding tubes are a last resort, inserted at the stomach wall.

I've lost weight and also muscle tone. My arms fatigue easily. How would I know the difference between sarcopenia from inactivity and cancer cachexia?

See a doctor. The symptoms you described warrant a more detailed history, physical examination and may be some tests. It would be prudent to consult your doctor for an evaluation. In mean time try doing some exercise, even just walking and increase the pace gradually over days and weeks. If the weakness is due to inactivity, it will improve with time. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts of lean meats. Avoid saturated fats. Drink enough water daily, so that your urine is mostly colorless. Exercise at least 150 minutes/week and increase the intensity of exercise gradually. Do not use tobacco, alcohol, weed or street drugs in any form. Practice safe sex.