Please explain how estradiol is a carcinogen?

Indirectly. The principal cause of cancer is things which increase the division rate of cells beyond their natural rate leading to an increase in mistakes which can lead to cancer. Estradiol augments the natural estrogen, cause estrogen sensitive cells to divide at a rate beyond their natural programming. This is especially true for the breast, and this leads to an increase in breast cancer.

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Can someone please explain how estradiol is a carcinogen?

Growth promotion. Carcinogens cause dna damage or promote cell growth. Estradiol, while a natural hormone, it promotes cell growth in breast and reproductive organs and potentiates the effects of carcinogens. Read more...