What can I get from home depot that kills bedbugs?

Not much. Declutter entire bedroom & any other effected rooms. Check this site for instructions: http://treatmentforbedbugs.Com/ place all junk in tightly sealed plastic & dispose of it. Wash clothing, linens, towels in hot water. Dry on highest heat - then repeat. Place clean items in a sealed bag to prevent re-infestation. Steam clean what you can't place in drier. Vacuum everything using a >.
Pesticides, vacuum. Eradication of bed bugs frequently requires a combination of pesticide and non-pesticide approaches. Pesticides include pyrethroids, dichlorvos and malathion. Resistance to pesticides has increased a lot over time, so mechanical approaches such as vacuuming up the insects and heat treating or wrapping mattresses have been recommended.