What is considered treatment resistant depression?

Failure of one med. Treatment-resistant depression (TRD) typically refers to inadequate response to at least one antidepressant trial of adequate doses and duration. TRD is a relatively common occurrence in clinical practice, with up to 50% to 60% of the patients not achieving adequate response following antidepressant treatment.
A formidable emotion. Trd is a type of depression that fails to respond to standard clinical treatments (psychotherapy, medication) over a prescribed period of time. Trd symptoms can range from mild to severe and during the course of care may require combination treatments and ancillary services, such as functional/environmental analysis, activity scheduling, and behavioral planning, .

Related Questions

Is there treatment-resistant depression?

Yes. But the definition is usually failure of 2-3 different treatments. Treatment-resistant doesn't mean incurable. Very often people have gotten multiple antidepressant trials without much benefit, but they were all similar medications or too short trials. There are many strategies and combinations as well as ECT that often work when others fail. See my book, psychiatry in techno colors. Read more...
Yes. It often requires more than one medication. The chances of getting complete resolution of symptoms on one drug is 30%, insomnia, daytime fatigue and pain are the common remaining sx's. If those aren't considered into your treatment plan, you may be changing to different single agents. Using more than one medicine may be key; modafanil for datime sleepiness can be a great adjunct, Abilify (aripiprazole) good. Read more...

What's the best treatment for, treatment resistant depression?

No 1 "best" one. There are many treatment augmenting strategies for treatment resistant depression. One that seems promising but has less side effects is l-methyl folate (folic acid), (folic acid) since many with depression have abnormalities of folate (folic acid) metabolism that can worsen depression. Also there are transcranial magnetic stimulation and ect. Ongoing psychotherapy of course. Plus many complementary forms of medicine as well. Read more...
A lot of options. Medication plus psychotherapy is usually effective, even in treatment resistant depression. Some fringe therapies are present like transmagnetic stimulation. Talk with your doctors about options that may work for you. Read more...

What are your options when you have treatment resistant depression? Any meds of last resort?

Meds and therapy. Meds alone can only help just so much; meds don't sure a person of depression, they just take the edge off the symptoms. The real grunt work takes place in therapy, which combined with meds is most optimal. Read more...
Depression. may be treated with different classes of antidepressants( selective serotonin reuptake inhibitors, serotonin-norepineprhine reuptake inhibitors, mood stabilizers, atypical antipsychotics & bupropion. Tricyclic antidepressants and monoamine oxidase inhibitors are often used off- label now (rather than for depression). Treatment option include > Read more...

What is your advice regarding divorcing while having major treatment resistant depression? Could it help the depression?

Uncertain. Divorce can have both effects on depression. It really depends on the marriage and the depression. I strongly recommend talking with a psychotherapist at length before making the decision to divorce and perhaps consider couples counseling in addition to individual therapy for yourself. Major depression and marital dissatisfaction are separate entities that can/do contribute to each other. Read more...
Need more info. It's hard to make a rational decision about anything when you are severely depressed. Is the marriage breaking up because you are depressed? Are you depressed because of the breakup? What have you done for the depression? Depression might be "treatment resistant" because drugs are not the answer, psychotherapy is. And many other questions. Read more...
Depends. Divorce is a major decision of life and has tremendous psychic impact even for a non-depressed person. Depression can cloud your judgment at times and itself is enough to strain relationships. On the other hand if your spouse is the trigger and cause for your depression it might help. Talk to your therapist/psychiatrist as the option of interpersonal and couples therapy should be explored. Read more...

How is the success of Lithium Therapy in unipolar treatment resistant depression?

It may help... Lithium has a fair amount of research behind it--it is a known strategy to augment antidepressant treatment and to help prevent recurrence. Patients seem to be afraid of Lithium; but for many people it can be a life-saver. Read more...
Good option. Lithium is another good option for augmenting the treatment of unipolar depression. The success rate of any new medication after the failure of several others is not going to be very high. Anti-depressants are only 30-40% effective or so. Check out ECT or TMS. Read more...

How is the success of Lithium Therapy in Atypical depression? Suffering from unipolar treatment resistant depression.

Treatment . Research suggests that lithium is effective 50% of the time when added to antidepressant medication to augment response in the treatment of depression. . Read more...

What is the current thinking on BPD and treatment resistant depression? Is there anything new in the pipeline at the moment?

BPD ? KatieM881~ here are some references for you to read for latest treatment for BPD: http://bipolar.stanford.edu/documents/3.WangNewBP.Rx.MoodD.EdDay10.Final.pdf http://www.nimh.nih.gov/news/science-news/science-news-about-bipolar-disorder.shtml https://www.seroquelxrtouchpoints.com/bipolar-disorder/bipolar-depression-efficacy?source=SERH34439&WT.mc_id=SERH34439&umedium=paid%20search&uadpub=google. Read more...

How is the tolerability and adverse effect of Moclobemide in treatment resistant depression? If other options didn't work.

Talk with Doctor. This should be discussed with your physician who is familiar with the problem you are having. Read more...
Follow directions. Ok if you follow precautions--your other docs won't like it because it interacts with many Meds--I've treated any pts on Nardil & Parnate (tranylcypromine) over the years & it can be done successfully. Read more...

Has anyone ever heard of a vagal nerve stimulator for treatment resistant depression?

Yes. Vns may be used to treat seizures or depression. Insurance only covers its exorbitant cost for treatment of seizures ($30k). The vagus nerve seems to have connections throughout the brain so by stimulating it, you may in turn stimulate many different brain areas. It's thought this relieves depression. About 1/3 of the most severe cases of depression get better w/ this treatment. Read more...
VNS for dep. Yes. I've heard of it, been to a conference on it, and heard dinner programs about it. It is exorbitantly expensive and was considered the end of the line treatment for depression a few years back. In my opinion, tms and some of the newer agents may work just as well. Read more...