6 doctors weighed in:
I am allergic to penicillin, can other antibiotics be used to treat syphilis?
6 doctors weighed in

Dr. James Ferguson
Pediatrics
4 doctors agree
In brief: Yes
It is known that 60-70% of those thought penicillin allergic are not, skin testing in a protected setting can usually provide more accurate status.
Nontheless, the drug Doxycycline given over a 2 wk period may cure syphillis, Azithromycin has been used but some resistant strains have been found. Penicillin is the only drug known effective during pregnancy & can be used with rapid desensitization.

In brief: Yes
It is known that 60-70% of those thought penicillin allergic are not, skin testing in a protected setting can usually provide more accurate status.
Nontheless, the drug Doxycycline given over a 2 wk period may cure syphillis, Azithromycin has been used but some resistant strains have been found. Penicillin is the only drug known effective during pregnancy & can be used with rapid desensitization.
Dr. James Ferguson
Dr. James Ferguson
Thank
Dr. Lee Perry
Internal Medicine - Allergy & Immunology
In brief: Penicillin is best
Depending on your history of penicillin allergy, you may need to be desensitized to penicillin prior to treatment.
I would first recommend consultation with an infectious disease specialist to determine potential alternative treatments.

In brief: Penicillin is best
Depending on your history of penicillin allergy, you may need to be desensitized to penicillin prior to treatment.
I would first recommend consultation with an infectious disease specialist to determine potential alternative treatments.
Dr. Lee Perry
Dr. Lee Perry
Thank
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