Does cyclosporine work on hives?

Yes. Cyclosporine and other potent immunosuppressant agents are very effective for hives. They are reserved for patients whose hives are resistant to medications with fewer side-effects and that require less on-going monitoring for safety.
Yes as last resort. Before trying cyclosporin you should, under an allergist's supervision, try Cetirizine 10 mg, 1-4 tabs per day and ranitidine (type 2 antihistamine) 300 mg per day. If this doesn't work then additional antihistamines can be added to the regimen. An allergist should be able to guide you through these steps, and others, before cyclosporin is considered.

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