3 doctors weighed in:
How does the drug carbidopa affect levodopa?
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In brief: Blocks breakdown
Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine.
Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed.

In brief: Blocks breakdown
Carbidopa acts to block the enzyme aromatic-l-amino-acid decarboxylase which converts l-dopa to dopamine.
Since it cannot get into the brain it works in the rest of the body (periphery). When given in combination with l-dopa in parkinson's disease, it inhibits the conversion of l-dopa to Dopamine in the body so that more is available to be converted in the brain where it is needed.
Dr. Darren Gitelman
Dr. Darren Gitelman
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