8 doctors weighed in:
What induces apoptosis in cancer cells?
8 doctors weighed in

Dr. Joseph Woods
Pathology
5 doctors agree
In brief: Many factors.
There are many factors/regulators that induce apoptosis in cancer and normal cells.
These are defective or turned off in cancer cells. For example, the x-linked inhibitor of apoptosis protein (xiap) is overexpressed in cancer cells. Xiaps bind to caspase-9, and suppress apoptotic activator cytochrom c, allowing the damaged cells to live. Deactivation of p53 apoptotic protein is another example.

In brief: Many factors.
There are many factors/regulators that induce apoptosis in cancer and normal cells.
These are defective or turned off in cancer cells. For example, the x-linked inhibitor of apoptosis protein (xiap) is overexpressed in cancer cells. Xiaps bind to caspase-9, and suppress apoptotic activator cytochrom c, allowing the damaged cells to live. Deactivation of p53 apoptotic protein is another example.
Dr. Joseph Woods
Dr. Joseph Woods
Thank
1 comment
Dr. Andrew Turrisi
BCL-2 is anti-apoptotic; balanced by BAX which is pro-apoptosis...a small cell mechanism...all chemo does not lead to apoptosis, Blocking bcl-2 or enhancing BAX promotes apoptostic death
Dr. David Masiello
Internal Medicine - Hematology & Oncology
2 doctors agree
In brief: Chemotherapy
All chemotherapy or treatment eventually leads to apoptosis or cell death.

In brief: Chemotherapy
All chemotherapy or treatment eventually leads to apoptosis or cell death.
Dr. David Masiello
Dr. David Masiello
Thank
1 comment
Dr. Foster Carr
CD8 T killer cells and Natural Killer Cells will also stimulate apoptosis of cancer cells.
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